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Old Yesterday, 11:46 AM  
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#1521
Ladyshopper
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Join Date: Apr 11
Originally Posted by MounjaroJourney View Post
I took my second dose of 2.5 on Sunday night. This time injected in my stomach - I could feel the needle this time, but only briefly and very mild.
Still no effect on feelings, cravings etc., good or bad. I'll continue with two (or possibly three) more 2.5 doses and then move up to 5. Hopefully that will see some sort of effect.
Does anyone know if its possible to be immune to Mounjaro?
I believe that the figure is around 15% of people it doesn't work for. However, it's impossible to say whether you're immune until you've worked through more of the doses. I think it's 12 weeks they suggest you try it for. moving up through each dose every 4 weeks.

2.5mg has done nothing for me, but I'm still hopeful it will work when I move up. On the other hand, my husband has decided to stick with 2.5mg for his next pen as it's working well for him.
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Old Yesterday, 12:06 PM  
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#1522
chubbs
Trying for More Ears
 
Join Date: Nov 24
A quick bit of ChatGPT research paraphrased...

Not getting any effect from Mounjaro is uncommon, but some people experience blunted effects and need higher doses in order for it to be effective.

Being effective means reducing your appetite rather than making you lose weight. Mounjaro makes it easier for you to lose weight, but if you continue to consume more energy than you're using you won't lose.

For people with increased insulin resistance it can also take longer to have an effect. Thyroid issues and certain medications can also blunt the effects. There are also genetic factors at play to do with the receptors that the drug targets.

The other issue is injection technique. I doubt anyone has this issue in real life, but incorrect injection technique could lead to absorption issues. For example, if you were injecting into muscle rather than subcutaneous fat.

The advice is to try at least 12 weeks at a therapeutic dose (5mg or above) before considering whether it is an ineffective treatment. 2.5mg is not considered a therapeutic dose.

If Mounjaro does not work after this time, a different drug (such as Wegovy) may still be effective.
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Old Yesterday, 06:24 PM  
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#1523
ScoopsAhoy
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Join Date: Apr 21
Location: Hertfordshire
Hello 👋 started my journey today!
Got accepted with SheMed and just received my first pen and I’ve just used it.
Was so nervous but didn’t actually feel anything at all.
They also sent me a little care package and the best part is it’s £99 a month no matter the dosage but I am locked in for 12 months so I I don’t want to do it anymore then I still get charged unless I have side effects then I don’t have to pay.
Hoping to lose about 4 stone but would be delighted with 3 🤞
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